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02 червня 2026 року 02.06.26

Vitalii Kostenko, M.D., Ph.D., Sc.D., Professor

Vitalii Kostenko, M.D., Ph.D., Sc.D., Professor

Pathophysiology

 

Highlights

Languages
  • Ukrainian, English
Gender
  • Male
PSMU Affiliations:
  • Department of Pathophysiology
Location:

 

About Prof. Vitalii Kostenko

Primary Academic Title
  • Doctor of Medical Sciences in Pharmacology (Dr. Habil.: postdoc degree since 2003)
  • Professor (Pathophysiology) since 2004
  • Philosophy doctor in Pathophysiology (Ph.D. since 1996)
Positions Held
  • 2004 – present Head of the Department of Pathophysiology

 

Background

Vitalii Kostenko is a researcher in the field of molecular pathophysiology. His research has elucidated the role of transcription factors in the mechanisms underlying civilization-related diseases and trauma (including cranial and maxillofacial injuries), as well as the molecular and metabolic effects of environmental pollutants in Ukraine (such as nitrates, fluorides, petroleum products, etc.), disruptions of circadian and dietary patterns, and their contribution to the pathogenesis of systemic inflammation, metabolic syndrome, post-traumatic stress disorder, atherosclerosis, osteoporosis, peptic ulcer disease, and dental disorders. H-index: 10 in Scopus, 21 in Google Scholar. Under the direct supervision of Professor V.O. Kostenko, one doctoral dissertation and 19 PhD theses have been completed and defended, along with 8 dissertations for the Doctor of Philosophy degree in specialty 222 – Medicine. His scientific output includes >600 publications, 8 technologies, and 16 sectoral innovations in the healthcare system. He holds 33 patents of Ukraine for inventions and utility models. He is a co-author of three textbooks on pathophysiology, including two in English ("Pathophysiology" and "General and Clinical Pathophysiology"), which have been reprinted multiple times, and thirty-three educational manuals, three of which were published abroad.

Research Interests
  • Pathophysiology
  • Pharmacology
  • Molecular pathology
  • Metabolic diseases

Researcher unique identifier: 0000-0002-3965-1826

Scopus Author ID 7005666852

 

Expertise

Education

2004

Professor (Department of  Pathophysiology); Ukrainian Medical Stomatological Academy, Poltava, Ukraine.

2003

Doctor of Medical Sciences in Pharmacology; Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine.

1996

PhD (Candidate of Medical Sciences) in Pathological Physiology; Bogomoletz Institute of Physiology, National Academy of Science of Ukraine, Kyiv, Ukraine.

1992-1995

Post-graduate studies in the Specialty "Pathological Physiology", Ukrainian Medical Stomatological Academy, Poltava, Ukraine.

1984-1992

Medical School in the Specialty “General medicine”, Poltava State Medical Stomatological Institute, Poltava, Ukraine.
Selected Publications

Textbooks

1. Gozhenko AI, Szarpak L, Kubyshkin AV, Savytskyi IV, Kostenko VO, et al. General and Clinical Pathophysiology. 5th ed. Vinnytsia: Nova Knyha; 2021. 696 p.

2. Krishtal NV, Mikhnev VA, Zayko MN, Kostenko VO, et al. Edited by Krishtal NV, Mikhnev VA. Pathophysiology: textbook. 3rd ed Кyiv: Medicine Publishing; 2019. 656 p.

3. Zayko MN, Byts YV, Kryshchal MV, Kostenko VO, et al. Patofiziolohiia: pidruchnyk [Pathophysiology: textbook]. 6th ed. Kyiv: Medicine Publishing; 2017. 736 p. (Ukrainian)

Monograph

Chebotar LD, Tsvyakh OO, Laricheva OM, Pshichenko VV, Frankel YD, Anasevich YM, Solovyov VV, Kuznetsova TY, Kostenko VO, Solovyova NV. Organ effects of melatonin: a monograph. Mykolaiv: Ilyon; 2018. 236 с. (Ukrainian)

Selected articles

  • Kuryata O, Akimov O, Riabushko M, Kostenko H, Kostenko V, Mishchenko A, Nazarenko S, Solovyova N, Kostenko V. Therapeutic potential of 5-aminolevulinic acid in metabolic disorders: Current insights and future directions. iScience. 2024 Nov 26;27(12):111477. doi: 10.1016/j.isci.2024.111477. (Scopus, Q1)
  • Golovach I, Rekalov D, Akimov OY, Kostenko H, Kostenko V, Mishchenko A, Solovyova N, Kostenko V. Molecular mechanisms and potential applications of chondroitin sulphate in managing post-traumatic osteoarthritis. Reumatologia. 2023;61(5):395-407. doi: 10.5114/reum/172211.  (Scopus, Q3)
  • Opryshko V, Prokhach A, Akimov O, Riabushko M, Kostenko H, Kostenko V, Mishchenko A, Solovyova N, Kostenko V. Desmodium styracifolium: Botanical and ethnopharmacological insights, phytochemical investigations, and prospects in pharmacology and pharmacotherapy. Heliyon. 2024 Jan 20;10(3):e25058. doi: 10.1016/j.heliyon.2024.e25058. (Scopus, Q1)
  • Kostenko V, Akimov O, Gutnik O, Kostenko H, Kostenko V, Romantseva T, Morhun Y, Nazarenko S, Taran O. Modulation of redox-sensitive transcription factors with polyphenols as pathogenetically grounded approach in therapy of systemic inflammatory response. Heliyon. 2023 Apr;9(4):e15551. doi: 10.1016/j.heliyon.2023.e15551. (Scopus, Q1)
  • Frenkel Y, Cherno V, Kostenko H, Kostenko V. Resveratrol attenuates the development of nitro-oxidative stress in the liver of rats under a round-the-clock lighting and high-carbohydrate-lipid diet. Romanian Journal of Diabetes, Nutrition and Metabolic Diseases. 2023;30(1):48-54. DOI: 10.46389/rjd-2023-1217 (Scopus)
  • Frenkel Y, Cherno V, Kostenko H, Chopra H, Gautam RK, Kostenko V. Dietary Supplementation with Resveratrol Attenuates Serum Melatonin Level, Pro-Inflammatory Response and Metabolic Disorder in Rats Fed High-Fructose High-Lipid Diet under Round-the-Clock Lighting. Pathophysiology. 2023 Feb; 30(1):37-47. DOI: 10.3390/pathophysiology 30010005 (Scopus, Q2)
  • Frenkel YD, Cherno VS, Zyuzin VO, Pshychenko VV, Starchenko II, Kostenko VO, Stepanchuk AP. Pathomorphological state of liver tissues in rats with experimental metabolic syndrome with quercetin correction. World of Medicine and Biology. 2023;(1):242-247. (Web of Science)
  • Taran OV, Solovyova NV, Kostenko VO. Effect of laparatomy and lipopolysaccharide-induced systemic inflammatory response on metabolic disorders in rats. Fiziol Zh. 2022;68(3):35-43. (Scopus)
  • Frenkel YD, Cherno VS, Kostenko VO. Nrf2 induction alleviates metabolic disorder and systemic inflammatory response in rats under a round-the-clock lighting and high-carbohydrate–lipid diet. Romanian Journal of Diabetes, Nutrition and Metabolic Diseases. 2022;29(2):194-201. (Scopus)
  • Kozaeva R, Klymenko MO, Katrushov OV, Kostenko VO. Bioflavonoids as agents for correcting nitro-oxidative stress and salivary gland functions in rats exposed to alcohol during modeled lipopolysaccharide-induced systemic inflammatory response. Wiadomości Lekarskie. 2022;75(3):685-690. (Scopus)
  • Yavtushenko IV, Nazarenko SM, Katrushov OV, Kostenko VO. Quercetin limits the progression of oxidative and nitrosative stress in the rats’ tissues after experimental traumatic brain injury. Wiadomości Lekarskie. 2020; LXXIIІ (10):2127-2132. (Scopus)
  • Akimov OY, Kostenko VO. Role of NF-κB transcriptional factor activation during chronic fluoride intoxication in development of oxidative-nitrosative stress in rat's gastric mucosa. J Trace Elem Med Biol. 2020 Apr 19;61:126535. doi: 10.1016/j.jtemb.2020.126535. (Scopus, Q1)
  • Kuznetsova TY, Solovyova NV, Solovyov VV, Kostenko VO. Antioxidant activity of melatonin and glutathione interacting with hydroxyl and superoxide anion radicals. Ukrainian Biochemical Journal. 2017;89(6):22-30. (Scopus)
Memberships
  • Member of the Ukrainian Scientific Society of Pathophysiologists
  • Member of the Lithuaian Scientific Society

 

Professional Activities

  • Deputy editor-in-chief of a peer-reviewed, scientific journal Aktualʹni problemy suchasnoyi medytsyny (ISSN 2077-1096 (print), ISSN 2077-1126 (online)).
  • Editorial Board Member for  Journal World of Medicine and Biology (ISSN 2079-8334), The Medical and Ecological Problems (ISSN  2073-4662).
  • Reviewer for scientific journals: Fiziol Zh, Ukr Biochem J, Medicina (Lithuanian University of Health Sciences, MDPI), Wiad Lek, etc..